Journal
JOURNAL OF CLINICAL MEDICINE
Volume 4, Issue 12, Pages 1960-1976Publisher
MDPI
DOI: 10.3390/jcm4121952
Keywords
claudin 1; breast cancer; EMT; high claudin; collective migration; interacting partners
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Funding
- Canadian Breast Cancer Foundation (Prairies-NWT)
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Claudin 1 is a small transmembrane protein responsible for maintaining the barrier function that exists between epithelial cells. A tight junction protein that regulates the paracellular transport of small ions across adjacent cells, claudin 1 maintains cellular polarity and plays a major role in cell-cell communication and epithelial cell homeostasis. Long considered to be a putative tumor suppressor in human breast cancer, new studies suggest a role much more complex. While most invasive breast cancers exhibit a down regulation or absence of claudin 1, some aggressive subtypes that exhibit high claudin 1 levels have now been described. Furthermore, a causal role for claudin 1 in breast cancer progression has recently been demonstrated in some breast cancer cell lines. In this review we highlight new insights into the role of claudin 1 in breast cancer, including its involvement in collective migration and epithelial mesenchymal transition (EMT).
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