Journal
WORLD ALLERGY ORGANIZATION JOURNAL
Volume 8, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1186/s40413-014-0047-7
Keywords
Administration routes; Allergen immunotherapy; Intralympathic; Vaccination
Categories
Funding
- Circassia
- Boehringer-Ingleheim
- ORA Inc.
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Gold Standard allergen-specific immunotherapy is associated with low efficacy because it requires either many subcutaneous injections of allergen or even more numerous sublingual allergen administrations to achieve amelioration of symptoms. Intralymphatic vaccination can maximize immunogenicity and hence efficacy. We and others have demonstrated that as few as three low dose intralymphatic allergen administrations are sufficient to effectively alleviate symptoms. Results of recent prospective and controlled trials suggest that this strategy may be an effective form of allergen immunotherapy.
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