Journal
CANCER INVESTIGATION
Volume 36, Issue 9-10, Pages 520-536Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2018.1533965
Keywords
EGR1; DMP1 (DMTF1); ARF; p53; PTEN; Tumor suppression; Signaling; Transcription; Nucleus; Nucleolus
Categories
Funding
- National Institutes of Health [NIH/NCI 2R01CA106314]
- American Cancer Society [ACS RSG-07-207-01-MGO]
- Susan G. Komen for the Cure [KG080179]
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Recent studies have indicated that EGR1 is a direct regulator of tumor suppressors including TGF beta 1, PTEN, and p53. The Myb-like transcription factor Dmp1 is a physiological regulator of the Arf-p53 pathway through transactivation of the Arf promoter and physical interaction of p53. The Dmp1 promoter has binding sites for Egr proteins, and Egr1 is a target for Dmp1. Crosstalks between p53 and PTEN have been reported. The Egr1-Dmp1-Arf-p53-Pten pathway displays multiple modes of interaction with each other, suggesting the existence of a functional network of tumor suppressors that maintain normal cell growth and prevent the emergence of incipient cancer cells.
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