Journal
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Volume 28, Issue 1, Pages 208-216Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-18-0079
Keywords
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Funding
- Cancer Research UK (CRUK) [C18281/A19169]
- Medical Research Council Integrative Epidemiology Unit at the University of Bristol
- Medical Research Council (MRC) [MC_UU_12013/2]
- CRUK [C18281/A19169]
- MRC [1000143, MR/M012190/1]
- Wellcome Trust [108902/15/Z]
- Academy of Finland [312476, 312477, C11043/A4286, C18281/A8145, C18281/A11326]
- National Institute for Health Research Biomedical Research Centre - US NIH [U19 CA 148537, X01HG007492, HHSN268201200008I]
- NIH NCI
- Cancer Research UK [C5047/A7357, C1287/A10118, C1287/A16563, C5047/A3354, C5047/A10692, C16913/A6135]
- European Commission [223175 (HEALTH-F2-2009-223175)]
- NIH Cancer Post Cancer GWAS initiative grant [1 U19 CA 148537 01]
- (GAME-ON initiative)
- Institute of Cancer Research
- Everyman Campaign
- Prostate Cancer Research Foundation
- Orchid Cancer Appeal, The National Cancer Research Network UK
- National Cancer Research Institute (NCRI) UK
- NIHR
- Royal Marsden NHS Foundation Trust
- NATIONAL CANCER INSTITUTE [ZIACP010195] Funding Source: NIH RePORTER
- Academy of Finland (AKA) [312476, 312477, 312477, 312476] Funding Source: Academy of Finland (AKA)
- MRC [MC_UU_00011/5, MC_UU_12013/1, MR/N003284/1, MC_UU_12013/2] Funding Source: UKRI
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Background: Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations using two-sample Mendelian randomization (MR). Methods: The case-control portion of the study was conducted in nine UK centers with men ages 50-69 years who underwent prostate-specific antigen screening for prostate cancer within the Prostate Testing for Cancer and Treatment (ProtecT) trial. Two data sources were used to appraise causality: a genome-wide association study (GWAS) of metabolites in 24,925 participants and a GWAS of prostate cancer in 44,825 cases and 27,904 controls within the Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. Results: Thirty-five metabolites were strongly associated with prostate cancer (P < 0.0014, multiple-testing threshold). These fell into four classes: (i) lipids and lipoprotein subclass characteristics (total cholesterol and ratios, cholesterol esters and ratios, free cholesterol and ratios, phospholipids and ratios, and triglyceride ratios); (ii) fatty acids and ratios; (iii) amino acids; (iv) and fluid balance. Fourteen top metabolites were proxied by genetic variables, but MR indicated these were not causal. Conclusions: We identified 35 circulating metabolites associated with prostate cancer presence, but found no evidence of causality for those 14 testable with MR. Thus, the 14 MR-tested metabolites are unlikely to be mechanistically important in prostate cancer risk. Impact: The metabolome provides a promising set of biomarkers that may aid prostate cancer classification.
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