Journal
CANCER CELL
Volume 34, Issue 6, Pages 996-+Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2018.10.016
Keywords
-
Categories
Funding
- German Federal Ministry of Education and Research (BMBF) [01KU1001 A, 01KU1505A]
- Arvid Nilsson Foundation
- Rigshospitalets forskningsfond
- Sander Stiftung [2015.010.1]
- ERC Starting Grant
- Helmholtz International Graduate School at the DKFZ
- Research Council of Norway [187615]
- US NIH Intramural Research Program [Z1AES103266]
Ask authors/readers for more resources
Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis <= 55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Our integrative analysis identified four molecular subgroups, including a particularly aggressive subgroup with recurrent duplications associated with increased expression of ESRP1, which we validate in 12,000 tissue microarray tumors. Finally, we combined the patterns of molecular co-occurrence and risk-based subgroup information to deconvolve the molecular and clinical trajectories of prostate cancer from single patient samples.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available