Journal
CANCER CELL
Volume 35, Issue 1, Pages 111-+Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2018.12.003
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Funding
- Collaborative Genome Program for Fostering New Post-Genome Industry [2012M3A9B9028156, NRF-2017M3C9A5031397]
- Institute for Basic Science - Korean Ministry of Science and ICT (MSIT) [IBS-R013-A1]
- Korea Institute of Science and Technology (KIST)
- U.S. National Cancer Institute's Office of Cancer Clinical Proteomics Research (Clinical Proteomic Tumor Analysis Consortium program-CPTAC)
- Korean Ministry of Health and Welfare
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We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune-and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.
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