Journal
CANCER CELL
Volume 35, Issue 1, Pages 10-15Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2018.11.009
Keywords
-
Categories
Funding
- NIH-NCI [5 P01CA087497 -17]
Ask authors/readers for more resources
We propose that initiating truncal mutations plays a special role in tumor formation by both enhancing the survival of the initiating cancer cell and by selecting for secondary mutations that contribute to tumor progression, and that these mutations often act in a tissue-preferred fashion. Here, we explain why inherited mutations often have different tissue specificities compared with spontaneous mutations in the same gene. Initiating truncal mutations make excellent neo-antigens for immunotherapy, and understanding why one mutation selects for a second mutation in a particular tissue type could one day aid in the design of gene-targeted combination therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available