Journal
ACTA PHARMACEUTICA SINICA B
Volume 5, Issue 3, Pages 169-175Publisher
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2015.03.001
Keywords
Nanocarrier; Co-delivery; Chemotherapeutic drug; Gene; Liposome; Micelle; Dendrimer; Supramolecular system
Categories
Funding
- National Natural Science Foundation of China [81373342]
- Beijing Natural Science Foundation [2141004, 7142114]
Ask authors/readers for more resources
The efficacy of chemotherapeutic drug in cancer treatment is often hampered by drug resistance of tumor cells, which is usually caused by abnormal gene expression. RNA interference mediated by siRNA and miRNA can selectively knock down the carcinogenic genes by targeting specific mRNAs. Therefore, combining chemotherapeutic drugs with gene agents could be a promising strategy for cancer therapy. Due to poor stability and solubility associated with gene agents and drugs, suitable protective carriers are needed and have been widely researched for the co-delivery. In this review, we summarize, the most commonly used nanocarriers for co-delivery of chemotherapeutic drugs and gene agents, as well as the advances in co-delivery systems. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medial., Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available