Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 176, Issue 2, Pages 189-196Publisher
WILEY
DOI: 10.1111/bph.14522
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Funding
- National Institutes of Health [R35 HL139945]
- Leducq Fondation (MIRVAD network)
- Vascular Research Training Grant [5T32HL007950-15]
- AHA MERIT
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R35HL139945, P01HL107205] Funding Source: NIH RePORTER
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Endothelial NOS (eNOS), and its product NO, are vital components of the control of vasomotor function and cardiovascular homeostasis. In the present review, we will take a deep dive into eNOS enzymology, function and mechanisms regulating endothelial NO. The mechanisms regulating eNOS and NO synthesis discussed here include alterations to transcriptional, post-translational modifications and protein-protein regulations. Also, we will discuss the phenotypes associated with various eNOS mutants and the consequences of a disrupted eNOS/NO cascade, highlighting the importance of eNOS function and vascular homeostasis.
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