4.5 Article

Sleep duration and risk of breast cancer: The JACC Study

Journal

BREAST CANCER RESEARCH AND TREATMENT
Volume 174, Issue 1, Pages 219-225

Publisher

SPRINGER
DOI: 10.1007/s10549-018-4995-4

Keywords

Sleep duration; Breast cancer; Incidence; Cohort study; Postmenopausal; Parity; Japan

Categories

Funding

  1. Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) (Monbusho)
  2. MEXT (MonbuKagaku-sho) [61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, 17015022, 18014011, 20014026, 20390156, 26293138]
  3. Comprehensive Research on Cardiovascular and Life-Style Related Diseases [H26-Junkankitou [Seisaku]-Ippan-001, H29-Junkankitou [Seishuu]-Ippan-003]
  4. JSPS KAKENHI [JP 16H06277]
  5. CSC [201608050113]
  6. Grants-in-Aid for Scientific Research [26293138] Funding Source: KAKEN

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PurposeThe evidence on beneficial or adverse effects of sleep duration on risk of breast cancer remains controversial and limited, especially in Asia.MethodsA prospective study of 34,350 women aged 40-79years in whom sleep duration, and menstrual and reproductive histories were determined by a self-administered questionnaire. The follow-up period was from 1988 to 2009, and hazard ratios (HRs) with 95% confidence intervals (CIs) of breast cancer incidence were calculated for shorter sleep duration in reference to sleep duration of 8h/day by Cox proportional hazard models.ResultsDuring 19.2-year median follow-up (236 cases), we found a significant inverse association between sleep duration and risk of breast cancer, especially among postmenopausal women and women with low parity (nulliparous and women with <3 children); the multivariable HRs (95% CIs) among postmenopausal women who reported 7h/day and 6h/day of sleep in reference to 8h/day were 1.49 (0.81-2.76) and 1.98 (1.08-3.70) (P for trend=0.028), respectively, and the corresponding values among women with low parity were 1.50 (0.96-2.35) and 1.76 (1.01-2.79) (P for trend=0.018).ConclusionsShort sleep duration was associated with increased risk of incident breast cancer, especially among postmenopausal women and women with low parity.

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