Journal
BRAIN RESEARCH BULLETIN
Volume 151, Issue -, Pages 25-37Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2018.10.014
Keywords
Alzheimer's disease; Neuroinflammation; P1 receptor; P2X receptor; P2Y receptor
Categories
Funding
- National Institutes of Health [AG018357, DE017591, DE07389]
- BrightFocus Foundation [A20131715]
- Missouri Spinal Cord Research Program
- Food for the 21st Century Program of the University of Missouri
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by three major histopathological markers: amyloid-beta (A beta) plaques, neurofibrillary tangles and gliosis in the central nervous system (CNS). It is now accepted that neuroinflammatory events in the CNS play a crucial role in the development of AD. This review focuses on neuroinflammatory signaling mediated by purinergic receptors (P1 adenosine receptors, P2X ATP-gated ion channels and G protein-coupled P2Y nucleotide receptors) and how therapeutic modulation of purinergic signaling influences disease progression in AD patients and animal models of AD.
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