Journal
BRAIN IMAGING AND BEHAVIOR
Volume 14, Issue 2, Pages 321-328Publisher
SPRINGER
DOI: 10.1007/s11682-018-0022-y
Keywords
Parkinson's disease; COMT; MRI; Cognitive decline
Categories
Funding
- Fondo de Investigaciones Sanitarias del Ministerio de Sanidad y Consumo (Spain) [PI15/00962] Funding Source: Medline
- Fundació la Marató de TV3 [2014/U/477, 20142910] Funding Source: Medline
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The COMT Val(158)Met polymorphism has recently been identified as a predictor for cognitive decline in Parkinson's disease (PD). However, it remains unknown whether an early brain structural compromise could be involved in this clinical association. Here, in a cohort of 120 cognitively preserved de novo PD patients from the Parkinson's Progression Markers Initiative (PPMI) database, we found a widespread reduction in cerebral gray matter volume (GMV) in patients harboring the Val/Val genotype. The atrophic pattern included fronto-subcortical and parieto-temporal territories. Importantly, the GMV at some of the identified regions was associated with cognitive decline in a 4-year follow-up period. These findings suggest that GMV compromise in the early stages of PD may be a predisposing factor for cognitive decline of COMT Val/Val homozygotes.
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