Journal
BRAIN
Volume 142, Issue -, Pages 771-786Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awy347
Keywords
blood biomarker; tau; F-18-AV-1451; tau-PET; Alzheimer's disease
Categories
Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [2018R1A2A1A19019062, 2014M3C7A1046047, 2015M3C7A1028790, 2018R1A5A2025964]
- NRF [2014M3C7A1046042, 2015R1C1A2A01053545]
- National Research Foundation of Korea [2014M3C7A1046042, 2018R1A5A2025964, 2014M3C7A1046047, 2018R1A2A1A19019062, 2015R1C1A2A01053545, 2015M3C7A1028790] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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One of the hallmarks of Alzheimer's disease is abnormal deposition of tau proteins in the brain. Although plasma tau has been proposed as a potential biomarker for Alzheimer's disease, a direct link to brain deposition of tau is limited. Here, we estimated the amount of in vivo tau deposition in the brain by PET imaging and measured plasma levels of total tau (t-tau), phosphorylated tau (p-tau, T181) and amyloid-beta(1-42). We found significant correlations of plasma p-tau, t-tau, p-tau/amyloid-beta(1-42), and t-tau/amyloid-beta(1-42) with brain tau deposition in cross-sectional and longitudinal manners. In particular, t-tau/amyloid-beta(1-42) in plasma was highly predictive of brain tau deposition, exhibiting 80% sensitivity and 91% specificity. Interestingly, the brain regions where plasma t-tau/amyloid-beta(1-42) correlated with brain tau were similar to the typical deposition sites of neurofibrillary tangles in Alzheimer's disease. Furthermore, the longitudinal changes in cerebral amyloid deposition, brain glucose metabolism, and hippocampal volume change were also highly associated with plasma t-tau/amyloid-beta(1-42). These results indicate that combination of plasma tau and amyloid-beta(1-42) levels might be potential biomarkers for predicting brain tau pathology and neurodegeneration.
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