Journal
BRAIN
Volume 142, Issue -, Pages 70-79Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awy292
Keywords
dementia; Alzheimers; networks; connectivity; delusions
Categories
Funding
- Sidney R. Baer, Jr.
- NIH [R01MH113929, K23NS083741]
- Nancy Lurie Marks Foundation
- Dystonia Medical Research Foundation
- Alzheimer's Association
- BrightFocus Foundation
- Vanderbilt Faculty Research Scholars Award
- Academy of Finland [295580]
- Finnish Medical Foundation
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH113929] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K23NS083741] Funding Source: NIH RePORTER
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Studies of the same disease often implicate different brain regions, contributing to a perceived reproducibility crisis in neuroimaging. Using neurodegenerative disease as an example, Darby et al. report that different brain regions highlighted in different studies actually belong to common disease-specific networks, with specific symptoms localizing to common symptom-specific networks.Studies of the same disease often implicate different brain regions, contributing to a perceived reproducibility crisis in neuroimaging. Here, we leverage the normative human brain connectome to test whether seemingly heterogeneous neuroimaging findings localize to connected brain networks. We use neurodegenerative disease, and specifically Alzheimers disease, as our example as it is one of the diseases that has been studied the most using neuroimaging. First, we show that neuroimaging findings in Alzheimers disease occur in different brain regions across different studies but localize to the same functionally connected brain network. Second, we show that neuroimaging findings across different neurodegenerative diseases (Alzheimers disease, frontotemporal dementia, corticobasal syndrome, and progressive non-fluent aphasia) localize to different disease-specific brain networks. Finally, we show that neuroimaging findings for a specific symptom within a disease (delusions in Alzheimers disease) localize to a symptom-specific brain network. Our results suggest that neuroimaging studies that appear poorly reproducible may identify different regions within the same connected brain network. Human connectome data can be used to link heterogeneous neuroimaging findings to common neuroanatomy, improving localization of neuropsychiatric diseases and symptoms.
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