Journal
BONE MARROW TRANSPLANTATION
Volume 54, Issue 7, Pages 969-972Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41409-018-0412-1
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Funding
- 973 Program [2015CB964900]
- Natural Science Foundation of China [81470341, 81770201, 81730008]
- Key Project of Science and Technology Department of Zhejiang Province [2018C03016-2, 2015C03G2150011]
- Zhejiang public welfare foundation [GF18H180002]
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Adoptive transfer of T cells modified to express chimeric antigen receptors (CARs) targeting CD19 (CART19s) has demonstrated impressive results in treating B-cell malignancies. Although CART19-induced complications have been gradually recognized, local cytokine-release syndrome (CRS) at particular parts of the body has not been extensively studied. In this paper, we firstly present a successfully treated case of severe dyspnea caused by the rapid enlargement of cervical lymph node following CART19 therapy in a relapsed/refractory DLBCL patient, with emphasis on the recognition, workup, and treatment. This report reminds for a careful evaluation and observation of the pre-existing mass, which could enlarge rapidly again as a result of CRS and be life threatening, in the CART therapy.
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