4.7 Article

The Anaplasma ovis genome reveals a high proportion of pseudogenes

Journal

BMC GENOMICS
Volume 20, Issue -, Pages -

Publisher

BMC
DOI: 10.1186/s12864-018-5374-6

Keywords

Genome sequence; Comparative genomics; Vaccine development; Diagnostic assay; Rickettsial pathogen

Funding

  1. National Natural Science Foundation of China (NSFC) [31502091]
  2. 973 Program [2010CB530206, 2015CB150300]
  3. National Key Research and Development Program of China [2017YFD0501200, 2016YFC1202000, 2016YFC1202002, 2017YFD0502304, 2017YFD0500904]
  4. Agricultural Science and Technology Innovation Program (ASTIP) (CAAS-ASTIP-2016-LVRI)
  5. National Beef Cattle Industrial Technology System (NBCIS) [CARS-38]
  6. Jiangsu Co-innovation Center Program for Prevention and Control of Important Animal Infectious Diseases and Zoonoses

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Background: The genus Anaplasma is made up of organisms characterized by small genomes that are undergoing reductive evolution. Anaplasma ovis, one of the seven recognized species in this genus, is an understudied pathogen of sheep and other ruminants. This tick-borne agent is thought to induce only mild clinical disease; however, small deficits may add to larger economic impacts due to the wide geographic distribution of this pathogen. Results: In this report we present the first complete genome sequence for A. ovis and compare the genome features with other closely related species. The 1,214,674 bp A. ovis genome encodes 933 protein coding sequences, the split operon arrangement for ribosomal RNA genes, and more pseudogenes than previously recognized for other Anaplasma species. The metabolic potential is similar to other Anaplasma species. Anaplasma ovis has a small repertoire of surface proteins and transporters. Several novel genes are identified. Conclusions: Analyses of these important features and significant gene families/genes with potential to be vaccine candidates are presented in a comparative context. The availability of this genome will significantly facilitate research for this pathogen.

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