Journal
BIOTECHNOLOGY LETTERS
Volume 41, Issue 1, Pages 27-34Publisher
SPRINGER
DOI: 10.1007/s10529-018-2619-z
Keywords
Bioproduction improvement; Heterologous biosynthesis; Modular co-culture engineering; Natural product; Plants and fungus
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Funding
- Rutgers, The State University of New Jersey
- CSC PhD fellowship
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Heterologous biosynthesis has been long pursued as a viable approach for high efficiency production of natural products with various industrial values. Conventional methods for heterologous biosynthesis use the mono-culture of an engineered microbe for accommodating the whole target biosynthetic pathway to produce the desired product. The emergence of modular co-culture engineering, which divides the pathway between multiple co-culture strains, presents a new perspective to conduct heterologous biosynthesis and improve the bioproduction performance of natural products. This review highlights recent advances in utilizing the modular co-culture engineering approaches to address the challenges of plant and fungal natural product biosynthesis. Potential directions for future research in this promising field are also discussed.
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