Journal
BIOTECHNOLOGY ADVANCES
Volume 38, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2019.01.004
Keywords
Plant natural products; Botanical dietary supplements; Cancer chemotherapeutic agents; Dereplication analytical methods; Molecular networking; 2D and 3D cell cultures; Micelles; Nanoparticles; Antibody-drug conjugates (ADCs).
Categories
Funding
- National Cancer Institute, National Institutes of Health, Bethesda, MD, USA [U19 CA52956, P01 CA125066]
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Higher plant constituents have afforded clinically available anticancer drugs. These include both chemically unmodified small molecules and their synthetic derivatives currently used or those in clinical trials as antineoplastic agents, and an updated summary is provided. In addition, botanical dietary supplements, exemplified by mangosteen and noni constituents, are also covered as potential cancer chemotherapeutic agents. Approaches to metabolite purification, rapid dereplication, and biological evaluation including analytical hyphenated techniques, molecular networking, and advanced cellular and animal models are discussed. Further, enhanced and targeted drug delivery systems for phytochemicals, including micelles, nanoparticles and antibody drug conjugates (ADCs) are described herein.
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