Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 29, Issue 1, Pages 32-35Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.11.021
Keywords
Pyrrole; Oxindole; Acridone; Molecular modeling; Tyrosine kinase; Anticancer
Categories
Funding
- Science and Engineering Research Board - Department of Science and Technology, New Delhi
- UGC, New Delhi
- University Grants Commission, New Delhi
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Based on the molecular modelling studies, a rational modification of the lead molecule was made to develop highly potent compounds showing anti-cancer activity against human breast cancer cell lines MCF 7, MDA-MB-468 and T-47D. The most potent compounds have Log P and total polar surface area 4.4-5.4 and 59.8 angstrom, respectively and they also exhibited promising ADME profile.
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