Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 29, Issue 2, Pages 185-188Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.12.004
Keywords
Cembrane; South China Sea; Absolute configuration; Sinularia flexibilis; Anti-inflammatory effect
Categories
Funding
- National Key Research and Development Program of China [2018YFC0310903, 2017YFE0103100]
- National Natural Science Foundation of China (NSFC) [81520108028, 21672230, 81603022, 81773628, 81741165, 41776139]
- National Natural Science Foundation of Zhejiang Province [LY16H300008, LY16H300007]
- SKLDR/ SIMM Project [SIMM1705ZZ-01]
- Youth Innovation Promotion Association from Chinese Academy of Sciences [2016258]
- SA-SIBS Scholarship Program
Ask authors/readers for more resources
Different chemotypes of Sinularia flexibilis exist in the Hainan island. Thus, a collection of this soft coral from a location different from the one of our previous study afforded three novel cembranoid esters featuring a n-butyl alcohol moiety, a structural element rare in natural products of both terrestrial and marine origin. The structures of the new compounds were elucidated by detailed spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. In addition, the absolute stereochemistry of the previously reported diepoxycembrene (9) was first time determined by the X-ray diffraction analysis. In bioassays, compounds 6-8 exhibited strong anti-inflammatory effect with IC50 values of 2.7, 4.7, and 4.2 mu M, respectively, whereas compound 5 displayed cytotoxicity against several cancer cells with IC50 values ranging from 8.9 to 27.4 mu M. A preliminary structural-activity relationship (SAR) was also described.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available