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Hyperbaric oxygen therapy: Antimicrobial mechanisms and clinical application for infections

Journal

BIOMEDICINE & PHARMACOTHERAPY
Volume 109, Issue -, Pages 440-447

Publisher

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2018.10.142

Keywords

Hyperbaric oxygen therapy; Infection; Inflammation; Reactive oxygen species

Funding

  1. Immunology Research Center, Tabriz University of Medical Sciences

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Hyperbaric oxygen therapy (HBOT) is a treatment procedure that involves breathing 100% O-2 for a certain time and under a certain pressure. HBOT is commonly administrated as a primary or alternative therapy for different diseases such as infections. In this paper, we reviewed the general aspect of HBOT procedures, the mechanisms of antimicrobial effects and the application in the treatment of infections. Parts of the antimicrobial effects of HBOT are believed to result of reactive from the formation of reactive oxygen species (ROS). It is also said that HBOT enhances the antimicrobial effects of the immune system and has an additive or synergistic effect with certain antimicrobial agents. HBOT has been described as a useful procedure for different infections, particularly in deep and chronic infections such as necrotizing fasciitis, osteomyelitis, chronic soft tissue infections, and infective endocarditis. The anti-inflammation property of HBOT has demonstrated that it may play a significant role in decreasing tissue damage and infection expansion. Patients treated by HBOT need carful pre-examination and monitoring. If safety standards are strictly tracked, HBOT can be considered a suitable procedure with an apt rate of complication.

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