Journal
BIOMARKERS IN MEDICINE
Volume 13, Issue 1, Pages 33-43Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2018-0169
Keywords
autoantibodies; biomarker; disease activity; India; inflammatory markers; MMP-9; mRNA expression; polymorphism; SLE; TIMP-1
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Funding
- Indian Council of Medical Research (ICMR), New Delhi, India
- University of Mumbai
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Aim: To investigate the possible association between MMP-9 (-1562 C/T) and TIMP-1 (372 T/C) polymorphism and inflammatory markers with disease activity in systemic lupus erythematosus (SLE) patients. Materials & methods: 150 SLE patients were recruited. Disease severity was assessed by SLEDAI (SLE disease activity index). The polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and serum levels by ELISA. Results: Among patients mean MMP-9 serum levels and mRNA expression were significantly decreased with increase in TIMP-1 levels (p <0.0001). Concomitant presence of both MMP-9 1562 T and TIMP-1 372 C alleles synergistically increased risk of SLE by 7.89-fold (p <0.0001). The mRNA expression of MMP-9 and TIMP-1 correlated with SLEDAI score. Conclusion: MMP-9, TIMP-1 and MMP-9/TIMP-1 ratios may act as biomarkers for susceptibility to SLE.
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