Journal
BIOMARKERS IN MEDICINE
Volume 12, Issue 11, Pages 1291-1302Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2018-0217
Keywords
autoimmune disease; biomarker; interleukin-8; meta-analysis; systemic lupus erythematosus
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Funding
- National Natural Science Foundation of China [81573222]
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Aim: We performed thismeta-analysis in order to evaluate circulating interleukin-8 (IL-8) levels in systemic lupus erythematosus (SLE) patients more accurately and explore its related influencing factors. Methods: The related literature was systematically searched in PubMed, Embase and The Cochrane Library database (up to 28 March 2018). All data analysis was performed by Stata 12.0 software. Results: The results showed SLE patients had a higher circulating IL-8 levels than normal controls (pooled standardized mean difference = 0.963; 95% CI: 0.416-1.511). Subgroup analyses indicated SLE patients with age <40 years, Asia group and disease duration <10 years had higher IL-8 levels. Conclusion: Compared with normal controls, circulating IL-8 levels in SLE patients are elevated and affected by age, region and disease duration. [GRAPHICS]
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