Journal
BIOMACROMOLECULES
Volume 20, Issue 1, Pages 454-468Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.8b01661
Keywords
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Funding
- National Health and Medical Research Council (NHMRC) of Australia [1081944, 1042298]
- Science and Industry Endowment Fund (John Stocker Fellowship) [PF16-122]
- Rebecca L Cooper Medical Research Foundation [10770]
- Evans Foundation
- CSIRO, Clayton Australia
- Victorian Government's Operational Infrastructure Support Program
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The current urogynecological clinical meshes trigger unfavorable foreign body response which leads to graft failure in the long term. To overcome the present challenge, we applied a tissue engineering strategy using endometrial SUSD2+ mesenchymal stem cells (eMSCs) with high regenerative properties. This study delves deeper into foreign body response to SUSD2+ eMSC based degradable PLACL/gelatin nanofiber meshes using a mouse model targeted at understanding immunomodulation and mesh integration in the long term. Delivery of cells with nanofiber mesh provides a unique topography that enables entrapment of therapeutic cells for up to 6 weeks that promotes substantial cellular infiltration of host anti-inflammatory macrophages. As a result, degradation rate and tissue integration are highly impacted by eMSCs, revealing an unexpected level of implant integration over 6 weeks in vivo. From a clinical perspective, such immunomodulation may aid in overcoming the current challenges and provide an alternative to an unmet women's urogynecological health need.
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