Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 191, Issue 1, Pages 81-87Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-018-1597-2
Keywords
Oxidovanadium(IV); Metvan; DFT calculations; FTIR spectrum; Human bone and colorectal cancer cell lines
Funding
- Universidad Nacional de La Plata [X/690, X/673]
- Agencia Nacional de Promocion Cientifica y Tecnologica-ANPCyT [PICT 2014-2223]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas-CONICET [PIP 0034]
- CONICET
Ask authors/readers for more resources
The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study. The complex was also characterized by a detailed analysis of its infrared spectrum, supported by the theoretical calculations, and also by some data derived from its Raman spectrum. In addition, cytotoxicity studies were performed using human osteosarcoma (MG-63) and human colorectal adenocarcinoma (HT-29) cell lines. The results show that Metvan impaired cell viability of both cancer cell lines in a low concentration range (0.25-5.0 mu M).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available