Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 41, Issue 12, Pages 1818-1823Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b18-00512
Keywords
nitrite; nitrate; nitric oxide; pulmonary emphysema; elastase; chronic obstructive pulmonary disease (COPD)
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Pulmonary emphysema (PE) is a major pathological feature of chronic obstructive pulmonary disease (COPD) and is characterized by proteolytic destruction of the alveolar structure and subsequent inflammation of the respiratory tract. We hypothesized that nitrite attenuates the development of PE via anti-inflammatory actions. PE was induced by intratracheal instillation of porcine pancreas elastase (PPE) in mice. Dietary nitrite dose-dependently (50 and 150 mg/L in drinking water) attenuated emphysematous development and macrophage accumulation in the alveolar parenchyma 21 d after PPE treatment. The present study shows that dietary nitrite might be a possible nutritional strategy in preventing the development of PE in mice.
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