Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1871, Issue 1, Pages 50-63Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2018.10.006
Keywords
Cancer stem cells; metabolic reprogramming; de-differentiation
Categories
Funding
- National Institutes of Health [P01 CA217798, R01CA183459, R01CA210637, UO1 CA200466, UO1 CA185148, UO1 CA210240, P50 CA127297]
- Nebraska Department of Health and Human ServicesLB595
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Cancer biology research over recent decades has given ample evidence for the existence of self-renewing and drug-resistant populations within heterogeneous tumors, widely recognized as cancer stem cells (CSCs). However, a lack of clear understanding about the origin, existence, maintenance, and metastatic roles of CSCs limit efforts towards the development of CSC-targeted therapy. In this review, we describe novel avenues of current CSC biology. In addition to cell fusion and horizontal gene transfer, CSCs are originated by mutations in somatic or differentiated cancer cells, resulting in de-differentiation and reprogramming. Recent studies also provided evidence for the existence of distinct or heterogeneous CSC populations within a single heterogeneous tumor. Our analysis of the literature also opens the doors for a novel hypothesis that CSC populations with specific phenotypes, metabolic profiles, and clonogenic potential metastasize to specific organs.
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