Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1871, Issue 1, Pages 75-84Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2018.11.001
Keywords
Pancreatic cancer; Exosomes; Diagnosis; Treatment; Prognosis; Drug delivery vehicle
Categories
Funding
- National Science Foundation of China [81572376, 81622049, 81871989]
- National Young Topnotch Talent program
- Shanghai Municipal Education Commission [17SG04]
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Pancreatic cancer is one of the most aggressive human malignancies and is associated with a dismal prognosis, which can be contributed to its atypical symptoms, metastatic propensity, and significant chemoresistance. Emerging evidence shows that pancreatic cancer cell-derived exosomes (PEXs) play critical roles in tumorigenesis and tumor development, as they are involved in drug resistance, immune evasion and metabolic reprograming, and distant metastasis of pancreatic cancer. Their numerous differentially expressed and functional contents make PEXs promising screening tools and therapeutic targets, which require further exploration. In this review, we focus on the functions of PEX contents and their clinical implications in pancreatic cancer.
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