4.4 Review

Transporter oligomerisation: roles in structure and function

Journal

BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 47, Issue -, Pages 433-440

Publisher

PORTLAND PRESS LTD
DOI: 10.1042/BST20180316

Keywords

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Funding

  1. European Union's Horizon 2020 research and innovation programme, RAMP-ITN: Rationalising Membrane Protein Crystallisation Innovative Training Network, under the Marie Sklodowska-Curie grant [722687]
  2. Imperial College London Institute of Chemical Biology Engineering and Physical Sciences Research Council CDT PhD studentship
  3. Biotechnology and Biological Sciences Research Council [BB/BB/N016467/1]
  4. BBSRC [BB/N016467/1, BB/K017292/1] Funding Source: UKRI

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Oligomerisation is a key feature of integral membrane transporters with roles in structure, function and stability. In this review, we cover some very recent advances in our understanding of how oligomerisation affects these key transporter features, with emphasis on a few groups of transporters, including the nucleobase ascorbate transporters, neurotransmitter sodium symporters and major facilitator superfamily members.

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