4.8 Article

Spermidine reduces cancer-related mortality in humans

Journal

AUTOPHAGY
Volume 15, Issue 2, Pages 362-365

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2018.1539592

Keywords

Autophagy; aging; Aspirin; immunosurveillance; inflammation

Categories

Funding

  1. Ligue contre le Cancer (equipe labellisee)
  2. Agence National de la Recherche (ANR)
  3. ERA-Net for Research on Rare Diseases
  4. Association pour la recherche sur le cancer (ARC)
  5. Canceropole Ile-de-France
  6. Fondation pour la Recherche Medicale (FRM)
  7. European Commission (ArtForce)
  8. European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR)
  9. European Research Council (ERC)
  10. Fondation Carrefour
  11. Inserm (HTE)
  12. Institut Universitaire de France
  13. LeDucq Foundation
  14. LabEx Immuno-Oncology
  15. Seerave Foundation
  16. SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
  17. SIRIC Cancer Research and Personalized Medicine (CARPEM)
  18. Paris Alliance of Cancer Research Institutes (PACRI)
  19. Austrian Science Fund FWF (Austria) [P23490-B20, P29262, P24381, P29203, P27893, I1000]
  20. RHU Torino Lumiere
  21. Institut National du Cancer (INCa)
  22. Austrian Science Fund (FWF) [P29262, P29203] Funding Source: Austrian Science Fund (FWF)

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A recent prospective epidemiological study suggested that an increase in the nutritional uptake of the natural polyamine spermidine is associated with reduced overall and cancer-specific mortality. Here, we speculate through which mechanisms spermidine might exert such oncopreventive effects.

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