Journal
AUTOPHAGY
Volume 15, Issue 1, Pages 165-168Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2018.1530929
Keywords
Autophagy; cancer; cardiovascular diseases; health span extension; longevity
Categories
Funding
- Ligue contre le Cancer (equipe labellisee)
- Agence National de la Recherche (ANR) - Projets blancs
- ANR
- ANR under the ERA-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ile-de-France
- Chancelerie des universites de Paris (Legs Poix), Fondation pour la Recherche Medicale (FRM)
- European Commission (ArtForce)
- European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR)
- European Research Council (ERC)
- Fondation Carrefour
- Institut National du Cancer (INCa)
- Inserm (HTE)
- Institut Universitaire de France
- LeDucq Foundation
- LabEx Immuno-Oncology
- RHU Torino Lumiere
- Seerave Foundation
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
- Austrian Science Fund FWF (Austria) [P23490-B20, P29262, P24381, P29203 P27893, I1000]
- SFB Lipotox [F3012]
- DKplus Metabolic and Cardiovascular Diseases [W1226]
- Bundesministerium fur Wissenschaft, Forschung und Wirtschaft
- Karl-Franzens University
- NAWI Graz
- BioTechMed-Graz flagship project EPIAge
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- Austrian Science Fund (FWF) [P27893, P29262] Funding Source: Austrian Science Fund (FWF)
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Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested. Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels.
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