Journal
AUSTRALIAN DENTAL JOURNAL
Volume 64, Issue 1, Pages 66-71Publisher
WILEY
DOI: 10.1111/adj.12661
Keywords
Casein phosphopeptide-amorphous calcium phosphate; ecological effects
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Contemporary caries prevention protocols recommend not only effective remineralizing agents but also ecological measures to reverse the dental plaque dysbiosis responsible for the disease pathogenesis. There is a high-level of evidence supporting the remineralizing efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) from studies around the world. Evidence is now emerging that CPP-ACP may also have a beneficial influence on the dental plaque microbial ecology and homeostasis. The ecological cariostatic effects of CPP-ACP are believed to be mediated predominantly through its anti-adhesion, buffering and biofilm disrupting actions. This review principally discusses the ecological mechanisms of CPP-ACP and presents the current evidence for its effects on the oral microbiome ecology.
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