Related references
Note: Only part of the references are listed.Lyn kinase plays important roles in erythroid expansion, maturation and erythropoietin receptor signalling by regulating inhibitory signalling pathways that control survival
Neli S. Slavova-Azmanova et al.
BIOCHEMICAL JOURNAL (2014)
The molecular regulation of Janus kinase (JAK) activation
Jeffrey J. Babon et al.
BIOCHEMICAL JOURNAL (2014)
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses
Leila N. Varghese et al.
BIOCHEMICAL JOURNAL (2014)
Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms
Neha Bhagwat et al.
BLOOD (2014)
Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease
Silvia Spoerl et al.
BLOOD (2014)
Open-label study of oral CEP-701 (lestaurtinib) in patients with polycythaemia vera or essential thrombocythaemia with JAK2-V617F mutation
Elizabeth Hexner et al.
BRITISH JOURNAL OF HAEMATOLOGY (2014)
Who climbs the tryptophan ladder? On the structure and function of the WSXWS motif in cytokine receptors and thrombospondin repeats
Johan G. Olsen et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2014)
Selective JAK inhibitors
Brian W. Dymock et al.
FUTURE MEDICINAL CHEMISTRY (2014)
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
Yibing Shan et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Tofacitinib versus Methotrexate in Rheumatoid Arthritis
Eun Bong Lee et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
Patrick J. Lupardus et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor
Andrew J. Brooks et al.
SCIENCE (2014)
Inhibition of IL-6 family cytokines by SOCS3
Jeffrey J. Babon et al.
SEMINARS IN IMMUNOLOGY (2014)
The role of pacritinib in the management of myelofibrosis
Vu H. Duong et al.
EXPERT REVIEW OF HEMATOLOGY (2014)
Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody
Sophie E. Broughton et al.
CELL REPORTS (2014)
Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy
Clifford Liongue et al.
FRONTIERS IN ONCOLOGY (2014)
Profile of pacritinib and its potential in the treatment of hematologic disorders
Eleftheria Hatzimichael et al.
JOURNAL OF BLOOD MEDICINE (2014)
gp130 activation is regulated by D2-D3 interdomain connectivity
Antje Schuett et al.
BIOCHEMICAL JOURNAL (2013)
Lymphoid malignancies: Another face to the Janus kinases
Linda M. Scott
BLOOD REVIEWS (2013)
Signalling by the βc family of cytokines
Timothy R. Hercus et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2013)
CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia
A. Pardanani et al.
LEUKEMIA (2013)
Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure
Xiaobo Wan et al.
PLOS COMPUTATIONAL BIOLOGY (2013)
Comprehensive review of JAK inhibitors in myeloproliferative neoplasms
Mohamad Bassam Sonbol et al.
THERAPEUTIC ADVANCES IN HEMATOLOGY (2013)
Regulation of JAK2 Activation by Janus Homology 2: Evidence from Molecular Dynamics Simulations
Shunzhou Wan et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
Priya Koppikar et al.
NATURE (2012)
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
Rajintha M. Bandaranayake et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis
Srdan Verstovsek et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity
Que T. Lambert et al.
BIOCHEMICAL JOURNAL (2011)
Orientation-specific signalling by thrombopoietin receptor dimers
Judith Staerk et al.
EMBO JOURNAL (2011)
Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation
Erin E. Matthews et al.
FASEB JOURNAL (2011)
Growth Hormone Signaling in Human T47D Breast Cancer Cells: Potential Role for a Growth Hormone Receptor-Prolactin Receptor Complex
Jie Xu et al.
MOLECULAR ENDOCRINOLOGY (2011)
Prolactin regulation of the prostate gland: a female player in a male game
Vincent Goffin et al.
NATURE REVIEWS UROLOGY (2011)
Effects of Clinically Relevant MPL Mutations in the Transmembrane Domain Revealed at the Atomic Level through Computational Modeling
Tai-Sung Lee et al.
PLOS ONE (2011)
Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6Rα Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex
Patrick J. Lupardus et al.
STRUCTURE (2011)
Activation of GH signaling and GH-independent stimulation of growth in zebrafish by introduction of a constitutively activated GHR construct
A. S. Ishtiaq Ahmed et al.
TRANSGENIC RESEARCH (2011)
Role of the growth hormone-IGF-1 axis in cancer
Yash Chhabra et al.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2011)
Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit
Michelle Perugini et al.
BLOOD (2010)
F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: Proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents
Norma E. Fox et al.
EXPERIMENTAL HEMATOLOGY (2010)
Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2
Isabelle Broutin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Crystal Structure of the Entire Ectodomain of gp130 INSIGHTS INTO THE MOLECULAR ASSEMBLY OF THE TALL CYTOKINE RECEPTOR COMPLEXES
Yibin Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
gp130 at the nexus of inflammation, autoimmunity, and cancer
J. S. Silver et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2010)
Structural Characterization of the Stem-Stem Dimerization Interface between Prolactin Receptor Chains Complexed with the Natural Hormone
Jan van Agthoven et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
The growth hormone receptor: mechanism of activation and clinical implications
Andrew J. Brooks et al.
NATURE REVIEWS ENDOCRINOLOGY (2010)
Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor
Tobin J. Cammett et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Turning the growth hormone receptor on: Evidence that hormone binding induces subunit rotation
David Poger et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)
The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity
Jianmin Ding et al.
BLOOD (2009)
The Influence of Domain Structures on the Signal Transduction of Chimeric Receptors Derived from the Erythropoietin Receptor
Wenhai Liu et al.
JOURNAL OF BIOCHEMISTRY (2009)
MPL mutations in myeloproliferative disorders:: analysis of the PT-1 cohort
Philip A. Beer et al.
BLOOD (2008)
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
Guido Hansen et al.
CELL (2008)
Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex
Georgios Skiniotis et al.
MOLECULAR CELL (2008)
JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells
Hui Jin et al.
MOLECULAR ENDOCRINOLOGY (2008)
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
Scott W. Rowlinson et al.
NATURE CELL BIOLOGY (2008)
Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity
Megumi Funakoshi-Tago et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F
Xiaohui Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
An unusual cytokine: Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor
Trevor Huyton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Evolution of class I cytokine receptors
Clifford Liongue et al.
BMC EVOLUTIONARY BIOLOGY (2007)
Role of the growth hormone (GH) receptor transmembrane domain in receptor predimerization and GH-induced activation
Ning Yang et al.
MOLECULAR ENDOCRINOLOGY (2007)
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
Linda M. Scott et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease
Lynda A. O'Sullivan et al.
MOLECULAR IMMUNOLOGY (2007)
Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
Ross L. Levine et al.
NATURE REVIEWS CANCER (2007)
Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function
Stephane Pelletier et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Ligand-independent dimerization of the human prolactin receptor isoforms: Functional implications
Samantha L. Gadd et al.
MOLECULAR ENDOCRINOLOGY (2006)
gp130 dimerization in the absence of ligand: Preformed cytokine receptor complexes
Stephanie Tenhumberg et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells
Christiane Stuhlmann-Laeisz et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
MPLW515L is anovel somatic activating mutation in myelofibrosis with myeloid metaplasia
Yana Pikman et al.
PLOS MEDICINE (2006)
Active conformation of the erythropoietin receptor - Random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains
XH Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor
J Staerk et al.
BLOOD (2006)
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
IS Lucet et al.
BLOOD (2006)
Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
XH Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
RJ Brown et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
G Skiniotis et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
The JAK/STAT signaling pathway
JS Rawlings et al.
JOURNAL OF CELL SCIENCE (2004)
The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper
WM Ruan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways
JJ Acosta et al.
MOLECULAR ENDOCRINOLOGY (2003)
Hexameric structure and assembly of the interleukin-6/IL-6 α-receptor/gp130 complex
MJ Boulanger et al.
SCIENCE (2003)
Dimerization and signal transduction of the growth hormone receptor
J Gent et al.
MOLECULAR ENDOCRINOLOGY (2003)
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
P Saharinen et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Epitope map for a growth hormone receptor agonist monoclonal antibody, MAb 263
Y Wan et al.
MOLECULAR ENDOCRINOLOGY (2003)
Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer
N Seubert et al.
MOLECULAR CELL (2003)
An activating mutation in the transmembrane domain of the granulocyte colony-stimulating factor receptor in patients with acute myeloid leukemia
LV Forbes et al.
ONCOGENE (2002)
Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain
SN Constantinescu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor
KF Kubatzky et al.
CURRENT BIOLOGY (2001)
Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation
K Lindauer et al.
PROTEIN ENGINEERING (2001)
Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation
SN Behncken et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common βc subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis
ME Dahl et al.
GENES TO CELLS (2000)