Journal
APPLIED SURFACE SCIENCE
Volume 463, Issue -, Pages 889-899Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2018.09.015
Keywords
Silicone; Catheters; Polysaccharides; Coating; Antifouling; Antibacterial
Categories
Funding
- Slovenian Research Agency [P2-0118]
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In this work, surfaces of casted silicone sheets and silicone tubes were functionalized with colloidal polysaccharide complexes (chitosan, carboxymethyl chitosan, and hyaluronic acid in combination with a lysine-based surfactant) in order to introduce antimicrobial and antifouling surface properties. The surface chemistry and morphology, as well as the chemical and mechanical stability of the coatings were characterized. For this purpose, different microscopic and spectroscopic methods, pH-potentiometric titrations and standard methods for evaluation of mechanical properties were used. Finally, the antimicrobial and antifouling properties of functionalized silicone materials were evaluated in vitro. The findings of the physicochemical characterization showed that a discontinuous 3-step dip-coating process can be successfully implemented to coat casted polydimethylsiloxane sheets and tubes with colloidal polysaccharide complexes. These coatings exhibit slow-release leaching in aqueous environment at pH 4.5, 7, and 8 and show very good stability against mechanical abrasion, thus displaying high stability potential during catheter insertion. The antimicrobial properties against gram-positive bacteria, gram-negative bacteria and fungi, showed inhibition of bacterial growth of up to 86%. Furthermore, the bacterial biofilm formation tests have revealed that the hyaluronic acid-surfactant coating exhibits high biofilm growth reduction.
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