Journal
APPLIED ORGANOMETALLIC CHEMISTRY
Volume 33, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/aoc.4643
Keywords
addition,catalysis, lactonization; phthalide; tandem reaction
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Funding
- Nature Science Foundation of Fujian Province, China [2016J01086]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- Chinese Academic of Sciences
- Fujian Institute of Research on the Structure of Matter
- Key Laboratory of Coal to Ethylene Glycol and Its Related Technology
- Priority Research Program of the Chinese Academy of Sciences
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Using chiral phosphoramide ligand 2d-Zn (II) complex derived from (1R,2R)-1,2-diphenylethylenediamine as the catalyst, we have developed efficient catalytic asymmetric 1,2-addition/lactonization tandem reactions of diverse organozinc reagents with varied methyl 2-formylbenzoates for the construction of optically enriched 3-aryl or alkyl substituted phthalides, which are significant building blocks of many important chiral pharmaceuticals and natural products. The corresponding products could be afforded with good to excellent yields (up to 95%) and moderate to good enantioselectivities (up to 89%).
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