Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 103, Issue 5, Pages 2353-2365Publisher
SPRINGER
DOI: 10.1007/s00253-019-09617-1
Keywords
Bacteroides; Inflammation; Lipopolysaccharide; Next-generation probiotics; Regulatory T cells
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Funding
- National Natural Science Foundation of China [31601452]
- National Natural Science Foundation of China Key Program [31530056]
- Natural Science Foundation of Jiangsu Province [BK20160175]
- National First-Class Discipline Program of Food Science and Technology [JUFSTR20180102]
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Lipopolysaccharide (LPS) can promote the expression of pro-inflammatory cytokines, damage the tight junction of epithelial walls, and thereby lead to chronic low-grade intestinal inflammatory disorders. Evidences of many beneficial functions from Bacteroides strains suggest their intervention capabilities in LPS-induced inflammation. In the present study, both healthy and LPS-treated mice were consistently treated with Bacteroides strains for 5days. The intestinal microbiota alteration, epithelial permeability, cytokine expression, and autoimmune and innate immune responses were analyzed. B. fragilis HCK-B3 and B. ovatus ELH-B2 from our laboratory collection were demonstrated to assist intestinal equilibrium by maintaining the diversity of gut microbiota and relieve LPS-induced inflammation by either modulating cytokine production or restoring the Treg/Th-17 balance. Our research indicated that the Bacteroides strains with capabilities of alleviating inflammation have the potential as therapeutics to prevent intestinal inflammatory disorders and provided scientific supports for discovering next-generation probiotics.
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