Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 103, Issue 1, Pages 201-209Publisher
SPRINGER
DOI: 10.1007/s00253-018-9491-6
Keywords
Aspergillus Niger; Yarrowia lipolytica; Citric acid; Production; Strategies
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Funding
- National Natural Science Foundation of China [11605259]
- western talents program of the Chinese Academy of Sciences [Y706030XB0]
- Open Project Program of the Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, China [KLCCB-KF201802]
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Aspergillus niger and Yarrowia lipolytica are highly important in citric acid (CA) production. To further minimize the cost of CA bio-production using A. niger and Y. lipolytica, some strategies (e.g., metabolic engineering, efficient mutagenesis, and optimal fermentation strategies) were developed to enhance CA production and low-cost carbon sources were also utilized to decrease CA bio-production cost. In this review, we summarize the recent significant progresses in CA bio-production, including metabolic engineering, efficient mutagenesis and screening methods, optimal fermentation strategies, and use of low-cost carbon sources, and future prospects in this field are also discussed, which could help in the development of CA production industry.
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