Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 31, Issue 12, Pages 858-873Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2018.7712
Keywords
reactive oxygen species; pulmonary circulation; alveolar development; thiol regulation
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Recent Advances: Based on recent discoveries, it is increasingly clear that cellular redox state and oxidation of signaling molecules are critical modulators of lung disease and represent a final common pathway that leads to poor respiratory outcomes. Critical Issues: Based on the wide variety of stimuli that alter specific redox signaling pathways, improved understanding of the disease and patient-specific alterations are needed for the development of therapeutic targets. Further Directions: For the full comprehension of redox signaling in pulmonary disease, it is essential to recognize the role of reactive oxygen intermediates in modulating biological responses. This review summarizes current knowledge of redox signaling in pulmonary development and pulmonary vascular disease.
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