Journal
ANNUAL REVIEW OF MEDICINE, VOL 70
Volume 70, Issue -, Pages 335-351Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-111717-122956
Keywords
fecal microbiota transplantation; FMT; Clostridioides/Clostridium difficile infection; CDI; inflammatory bowel disease; IBD; irritable bowel syndrome; IBS; hepatic encephalopathy
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Fecal microbiota transplantation (FMT) is a well-established treatment for recurrent Clostridioides difficile infection. FMT has become a more readily available and useful new treatment option as a result of stool banks. The current state of knowledge indicates that dysbiosis of the gut microbiota is implicated in several disorders in addition to C. difficile infection. Randomized controlled studies have shownFMTto be somewhat effective in treating ulcerative colitis, irritable bowel syndrome, and hepatic encephalopathy. In addition, FMT has been beneficial in treating several other conditions, such as the eradication of multidrug-resistant organisms and graft-versus-host disease. We expect that FMT will soon be implemented as a treatment strategy for several new indications, although further studies are needed.
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