Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 37, 2019
Volume 37, Issue -, Pages 125-144Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-042718-041607
Keywords
platelet; inflammation; innate immunity; acquired immunity
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Funding
- NHLBI NIH HHS [F31 HL145922] Funding Source: Medline
- NIAID NIH HHS [T32 AI007285] Funding Source: Medline
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Platelets have dual physiologic roles as both cellular mediators of thrombosis and immune modulatory cells. Historically, the thrombotic function of platelets has received significant research and clinical attention, but emerging research indicates that the immune regulatory roles of platelets may be just as important. We now know that in addition to their role in the acute thrombotic event at the time of myocardial infarction, platelets initiate and accelerate inflammatory processes that are part of the pathogenesis of atherosclerosis and myocardial infarction expansion. Furthermore, it is increasingly apparent from recent studies that platelets impact the pathogenesis of many vascular inflammatory processes such as autoimmune diseases, sepsis, viral infections, and growth and metastasis of many types of tumors. Therefore, we must consider platelets as immune cells that affect all phases of immune responses.
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