Journal
ANNUAL REVIEW OF GENETICS, VOL 52
Volume 52, Issue -, Pages 89-107Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120417-031353
Keywords
SMC complexes; structural maintenance of chromosomes; Smc5/6; DNA repair; SUMOylation; small ubiquitin-like modifiers; gene transcription; genome organization
Categories
Funding
- Medical Research Council [MC_U120074328] Funding Source: Medline
- Wellcome Trust [100955] Funding Source: Medline
- MRC [MC_U120074328] Funding Source: UKRI
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Smc5 and Smc6, together with the kleisin Nse4, form the heart of the enigmatic and poorly understood Smc5/6 complex, which is frequently viewed as a cousin of cohesin and condensin with functions in DNA repair. As novel functions for cohesin and condensin complexes in the organization of long-range chromatin architecture have recently emerged, new unsuspected roles for Smc5/6 have also surfaced. Here, I aim to provide a comprehensive overview of our current knowledge of the Smc5/6 complex, including its long-established function in genome stability, its multiple roles in DNA repair, and its recently discovered connection to the transcription inhibition of hepatitis B virus genomes. In addition, I summarize new research that is beginning to tease out the molecular details of Smc5/6 structure and function, knowledge that will illuminate the nuclear activities of Smc5/6 in the stability and dynamics of eukaryotic genomes.
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