Journal
BIOCHEMICAL JOURNAL
Volume 469, Issue -, Pages E9-E11Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20150598
Keywords
ACBD3; cholesterol; ERK; fatty acid; lipotoxicity; PARP
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In this issue of Biochemical Journal, Chen and colleagues characterize an interaction between ACBD3 (acyl-CoA-binding domain-containing 3) protein and PARP [poly(ADP-ribose) polymerase]-1 through the activation of ERKs (extracellular-signal-regulated kinases). This study envisages a pathway through which ABCD3 translates enhanced fatty acid levels to ERK and consequently PARP-1 activation. The consequences of PARP-1 activation lead to cellular and tissue damage, implying that the ACBD3/PARP-1 pathway is an important pathway in lipotoxicity events.
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