(Dynamic) Kinetic Resolution of Enamines/Imines: Enantioselective N-Heterocyclic Carbene Catalyzed [3+3] Annulation of Bromoenals and Enamines/Imines

The enantioselective N-heterocyclic carbene catalyzed [3+3] annulation of alpha-bromoenals by dynamic kinetic resolution (DKR) of enamines and normal resolution of alpha,alpha-disubstituted imines were developed. The corresponding substituted dihydropyridones were isolated in good yields with excellent diastereo- and enantioselectivities, and a high selective factor (up to 83) was realized for the resolution of alpha,alpha-disubstituted imines.