Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 4, Pages 1057-1061Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201811273
Keywords
antitumor agents; cancer treatment; drug delivery; organic photothermal agents; photothermal therapy
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Funding
- National Natural Science Foundation of China [21535004, 91753111, 21874086, 21602125, 21390411]
- Key Research and Development Program of Shandong Province [2018YFJH0502]
- Natural Science Foundation of Shandong Province [ZR2016BQ38]
- China Postdoctoral Science Foundation [40411585]
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The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual-targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells. The synthesized photothermal agent exhibited high photothermal conversion efficiency, low cytotoxicity, and good biological compatibility. In vivo experiments showed an excellent tumor inhibitory effect of the dual-targeted photothermal agent.
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