Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 7, Pages 2050-2054Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812878
Keywords
invivo cross-linking; inflammation; lanthanide; NIR-II bioimaging; ultra-small nanoparticles
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Funding
- National Key RAMP
- D Program of China [2017YFA0207303]
- National Natural Science Foundation of China [21725502]
- Key Basic Research Program of Science
- Technology Commission of Shanghai Municipality [17JC1400100]
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To improve the bioimaging signal-to-noise ratio (SNR), long-term imaging capability, and decrease the potential biotoxicity, an invivo cross-linking strategy was developed by using sub-10nm, glutathione-modified, lanthanide nanoprobes. After administration, the nanoprobes cross-link in response to reactive oxygen species (ROS) at the inflamed area and enable the quick imaging of ROS in the second near-infrared (NIR-II) window. These nanoprobes could be rapidly excreted due to their ultra-small size. This strategy may also be applied to other ultra-small contrast agents for the precise bioimaging by insitu lesion cross-linking.
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