Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 3, Pages 769-774Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201810878
Keywords
anti-tumor activity; bioactivity; black phosphorus; selective chemotherapy; two-dimensional materials
Categories
Funding
- National Natural Science Foundation of China [31600595, 31800832, 51672305]
- International Cooperation Project for Science and Research Plan of Shenzhen [GJHZ20160229195805334]
- Frontier Science Key Programs of Chinese Academy of Sciences [QYZDB-SSW-SLH034]
- China Postdoctoral Science Foundation [2017M622828]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [11301215, 11205617]
- City University of Hong Kong Strategic Research Grant (SRG) [7005105]
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Black phosphorus nanosheets (BPs) are demonstrated to be highly bioactive anti-cancer agents because of their inherent and selective chemotherapeutic effects. Fast intracellular biodegradation of BPs and acute elevation of phosphate anions were observed from different types of cancer cells due to the stronger intracellular oxidative stress and accelerated energy metabolism, but normal cells are not affected. Selective biodegradation of BPs induced G2/M phase arrest and subsequent apoptosis- and autophagy-mediated cell death in cancer cells but not normal cells. The selectivity was superior to that of the traditional chemotherapeutic agent, doxorubicin (DOX). In vivo assessment confirmed the efficiency of BPs in suppressing tumor growth. This study provides insights into nanostructured bioactive anti-cancer agents and reveals a new direction for nanomedicine research.
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