Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 6, Pages 1670-1673Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201811289
Keywords
chirality; deracemization; drug discovery; medicinal chemistry; synthetic methods
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Mefloquine is an important drug for prevention and treatment of malaria. It is commercially available as a racemic mixture, wherein only one enantiomer is active against malaria, while the other one causes severe psychotropic effects. By converting the drug into a compound that crystallizes as a racemizable racemic conglomerate, the deracemization of mefloquine into the desired enantiomer was achieved.
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