Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 51, Pages 16742-16747Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201810363
Keywords
fluorine; imaging agents; magnetic resonance imaging; multicolor imaging; nanoparticles
Categories
Funding
- MEXT, Japan [17H06409]
- JSPS A3 Foresight Program
- JSPS Asian CORE Program, Asian Chemical Biology Initiative
- Magnetic Health Science Foundation
- [25220207]
- [18H03935]
- [16K01933]
- Grants-in-Aid for Scientific Research [17H06409] Funding Source: KAKEN
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In vivo multicolor imaging is important for monitoring multiple biomolecular or cellular processes in biology. F-19 magnetic resonance imaging (MRI) is an emerging in vivo imaging technique because it can non-invasively visualize F-19 nuclei without endogenous background signals. Therefore, F-19 MRI probes capable of multicolor imaging are in high demand. Herein, we report five types of perfluorocarbon-encapsulated silica nanoparticles that show F-19 NMR peaks with different chemical shifts. Three of the nanoprobes, which show spectrally distinct F-19 NMR peaks with sufficient sensitivity, were selected for in vivo multicolor F-19 MRI. The nanoprobes exhibited F-19 MRI signals with three colors in a living mouse. Our in vivo multicolor system could be utilized for evaluating the effect of surface functional groups on the hepatic uptake in a mouse. This novel multicolor imaging technology will be a practical tool for elucidating in vivo biomolecular networks by F-19 MRI.
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