Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 51, Pages 16871-16876Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201811139
Keywords
decarbonylation; difluoromethylation; homogeneous catalysis; palladium; room temperature
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Funding
- Max-Planck-Institut fur Kohlenforschung
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Methods for the direct synthesis of difluoromethylated arenes are sparse, despite the importance of the difluoromethyl group in medical, agro-, and materials chemistry. A palladium-catalyzed decarbonylative cross-coupling reaction of acid chlorides with a difluoromethyl zinc reagent is achieved to access difluoromethylated compounds. The transformation proceeds at room temperature and shows broad functional group tolerance, thus providing a general and efficient method for decarbonylative difluoromethylation of a wide range of aromatic carboxylic acids.
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