Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 6, Pages 1684-1688Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201811668
Keywords
C-H activation; cobalt; cyclopeptides; metathesis; peptides
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Funding
- DFG (Gottfried-Wilhelm-Leibniz-Preis)
- Alexander von Humboldt foundation
- Onassis Foundation
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Bioorthogonal late-stage diversification of structurally complex peptides has enormous potential for drug discovery and molecular imaging. In recent years, transition-metal-catalyzed C-H activation has emerged as an increasingly viable tool for peptide modification. Despite major accomplishments, these strategies largely rely on expensive palladium catalysts. We herein report an unprecedented cobalt(III)-catalyzed peptide C-H activation, which enables the direct C-H functionalization of structurally complex peptides, and sets the stage for a multicatalytic C-H activation/alkene metathesis/hydrogenation strategy for the assembly of novel cyclic peptides.
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